Frequently Asked Questions
What will The One Health Company test?
Pharmaceuticals, biologics, injectables, large molecules, medical devices, and diagnostics. Purely efficacy testing. Our model is not meant to test toxicology or safety because it's far too risky for client-owned pets.
How will The One Health Company accomplish this?
The One Health Company is creating a massive recruitment network from which to enroll patients in our studies; this will be overseen by clinical research associates at each location, and would eventually integrate with the hospitals’ electronic medical record (EMR) systems to auto-flag cases of interest. This system is analogous to the way Phase III trials are conducted in humans. We estimate we will be able to compile a recruitment database of over 6 million ill animals per year.
Where will The One Health Company operate if it doesn’t own its own facilities?
We are creating a research network of veterinary schools and hospitals.
Who will perform the clinical trial interventions?
Interventions are conducted by Board Certified Veterinary specialists at the top veterinary schools and specialty veterinary hospitals in the World. .
Who will provide animal husbandry for the study subjects?
Animals enrolled in The One Health Company clinical trials remain with their owners and return home for care and return to the hospital for evaluation by a veterinary specialist. Because pets are family members we would never want to separate them from their families.
Why is it better for the animal to stay at home with their owners?
Owners know their animals and their one-on-one relationship with their animal will provide exemplary clinical feedback and care. Conversely, in a laboratory, animals are kept confined and are overseen en masse. Importantly, this also keeps the cost of the study down considerably.
What happens to the animals at the end of the study?
At the conclusion of the study, the animals in our studies stay with their owners and live their lives with their diseases ameliorated or healed.
How will participants be recruited?
- Veterinarians work with Pet Owners to recruit their ill pets into clinical trials
- Direct Email Marketing
- Strategic Relationships
To ensure robust recruitment we ensure that the welfare of the animals is always protected and put first. Incentives are aligned throughout the animal health value chain to ensure ample participation.
How will The One Health Company control for variables?
We can easily overcome variability with numbers to create greater statistical power. Phase III human trials are controlled identically. We can select exceptional study candidates from our large network of research partners and control for most variables. It is better to fail early on in animal studies, than in Phase III human studies. Right now, 92% of animal cancer trials fail in people, partially because testing on a nearly identical population of animals is not representative of the normal variation in disease.
We are able control for as much or as little as possible, and less control increases prognostic ability in Phase III.
How will The One Health Company find enough animals with common human diseases?
These dog breeds are known to have high rates of disease, making it extremely easy to find a large pool to create a statistically significant study.
Sample Spontaneous Disease Models - Why create disease that spontaneously occurs in high frequency?
- Cavalier King Charles - Vascular Septal Defects, Mitral Insufficiency
- German Shepard - Perianal Tumors, Hip and Elbow Dysplasia, Subaortic Stenosis, Hemophilia, Panosteitis
- Doberman - Cardiomyopathy, Hypothyroidism, vWD, Mast Cell Tumor
- Labrador Retriever - Cranial Cruciate Rupture, Arthritis, Hemangiosarcoma
- Golden Retriever - Non-Hodgkin's Lymphoma, Benign Splenic Hyperplasia
- Chihuahua - Luxating patellas, Melanoma, Bladder stones, Obesity
- Dachshund - Intervertebral Disk Disease, Mammary Carcinoma, Hypertension
- Aussie Shepard - Epilepsy, Progressive Retinal Atrophy
- Beagle - Glaucoma, Renal Amyloidosis, Sebaceous Gland Tumors
- Bassett Hound - Otitis externa, Carpus Valgus
- Boxers - Glioblastoma, Congestive Heart Failure, Mast Cell Tumors
- Bulldogs - Snoring, obesity, Pyoderma, Adenocarcinoma
- Cocker Spaniels - Dental Disease, Cleft Palate, Oropharyngeal Neoplasia, Hemophilia, IMPT, IMHA
- Lhasa Apso - Bladder Stones, Keratoconjunctivitis sicca, Retinal Atrophy, Renal Dysplasia
- Yorkie - Portosystematic Shunts, Legg-Perthes Disease, Retinal Dysplasia
- Poodle - Cataracts, Addison's, Neonatal Encephalopathy, Squamous Cell Carcinoma, Psoriasis
- Pomeranian - Alopecia, Cataracts, Dwarfism, Seizure
- Samoyed - Alport Disease, Idiopathic Pulmonary Fibrosis
- Westie - Diabetes mellitus, Melanoma, Transitional Cell Carcinoma, Fanconi
Some lifestyle diseases are extremely difficult to induce in laboratory animal models, such as Metabolic Syndrome (a combination of high blood pressure, diabetes, high cholesterol, and obesity, that increase the risk of stroke and heart disease). Yet these conditions exist commonly and naturally in pets.