The research is compelling.
The canine genome was mapped in 2005, marking a turning point in canine to human translation. Today, our scientific collaborators are mapping the canine immune system, while integrating genomic, proteomic and epigenetic data. Leveraging the progressively annotated canine genome allows us to have access to the real-time molecular profiling of canine samples to build disease signatures for diagnostic, therapeutic and prognostic purposes.
Overview of the Science Behind Comparative Medicine
LeBlanc A.K. AACR, 2016: Defining the Value of Comparative Approach to Cancer Drug Development
Jacob J.A. Jana, 2016: Researchers Turn to Canine Clinical Trials to Advance Cancer Therapies
Kol A. Science Translational Medicine, 2015. Companion animals: Translational scientist's new best friends
Schiffman J.D. & Breen M. Royal Society, 2015:Comparative oncology: what dogs and other species can teach us about humans with cancer
Anderson K.L. & Modiano J.F. 2015. Progress in Adaptive Immunotherapy for Cancer in Companion Animals: Success on the Path to Cure
Paoloni M. PLOS ONE, 2014: Prospective Molecular Profiling of Canine Cancer Provides a Clinically Relevant Comparative Model for Evaluating Personalized Medicine (PMed) Trials
Garner J.P. ILAR, 2014: The Significance of Meaning: Why Do Over 90% of Behavioral Neuroscience Results Fail to Translate to Humans, and What Can We Do to Fix It?
Richter S.H. at al. Nature Methods, 2009: Environmental standardization: cure or cause of poor reproducibility in animal experiments?
Comparative Medicine in the Media
The Globe and Mail. Heal, boy: How companion animals can help find cures for human cancer
Wall Street Journal: Why Dogs Are Some Scientists' New Best Friends
Chemical and Engineering News. Could Fido Fetch a Cure?
New Haven Register. Canine cancer vaccine study launched
New York Times. In Trial for New Cancer Drug, Family Pets Are Benefiting, Too.